Left ventricular hypertrophy in pediatric kidney transplant recipients: long-term follow-up study.

Abstract

Cross-sectional studies indicate that LVH, known cardiovascular risk factor, is frequent in pediatric patients post-kidney transplant. We performed a retrospective longitudinal analysis of echocardiographic data collected in children and adolescents who received kidney transplant from 1998 to 2003. The first echo was performed at a median time post-transplant of 14 months in 47 children; a second echo (echo 2) was carried out at a median time of 33 months in 31 and a third echo (echo 3) was performed at a median time of 49 months in 14 children. LVH was defined as LV mass index >/=95th percentile for children. LVH was present in echo 1 in 25 (54%) subjects. Systolic blood pressure (p = 0.02) and BMI (p = 0.02) independently predicted the LVH seen in echo1 in multivariate logistic regression. In 14 subjects with three consecutive echocardiograms LVM index significantly decreased from echo 1 to echo 2 and from echo 1 to echo3 (p < 0.05), but no significant changes were observed between echo 2 and echo 3. The overall prevalence of LVH remained unchanged but its severity significantly decreased during the follow-up. The results of the study suggest that despite regression of LVM index overtime-pediatric patients post-kidney transplant are at continuous risk for developing cardiovascular disease.

• Authors: Nathan Bullington, Janis Kartel, Philip Khoury, Mark Mitsnefes
• Journal: Pediatric transplantation (Pediatr Transplant) Vol. 10 Issue 7 Pg. 811-5 (Nov 2006) ISSN: 1397-3142 [Print] Denmark
• PMID: 17032427 (Publication Type: Journal Article)

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Cross-Sectional Studies
• Echocardiography
• Female
• Follow-Up Studies
• Humans
• Hypertrophy, Left Ventricular (diagnostic imaging, epidemiology, etiology)
• Kidney Transplantation (adverse effects)
• Male
• Prevalence
• Prognosis
• Retrospective Studies
• Severity of Illness Index
• Time Factors