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A comparison of the effects of pneumoperitoneum and laparotomy on natural killer cell mediated cytotoxicity and Walker tumor growth in Wistar rats.

AbstractBACKGROUND:
Surgical stress promotes impaired immunological function, which contributes to tumor growth. Natural killer activity (NKA) has a protective role in immunity to tumors. So, the aim of this experimental study was to assess tumor growth and (NKA) after pneumoperitoneum and laparotomy. METHODS; Sixty male Wistar rats were divided into three groups (anesthesia, CO2 pneumoperitoneum and laparotomy) plus ten controls. All experimental animals were inoculated subcutaneously with 8 x 105 Walker carcinosarcoma 256 cells. Animals were sacrificed on 1st(POD1) and 8th (POD8) postoperative day. Tumors were excised and weighed.
RESULTS:
On POD1 all animals had diminished NKA when compared to controls; NKA after pneumoperitoneum was significantly greater than after laparotomy. On POD8 all animals, except after laparotomy, reached NKA at controls levels. Tumor weight was significantly greater after laparotomy when compared to pneumoperitoneum.
CONCLUSIONS:
Pneumoperitoneum causes a less depressed NKA and less tumor growth when compared to laparotomy.
AuthorsPaulo Emilio Fuganti, Aldo Junqueira Rodrigues Júnior, Consuelo Junqueira Rodrigues, Maria Sato
JournalSurgical endoscopy (Surg Endosc) Vol. 20 Issue 12 Pg. 1858-61 (Dec 2006) ISSN: 1432-2218 [Electronic] Germany
PMID17031748 (Publication Type: Comparative Study, Journal Article)
Topics
  • Animals
  • Carcinoma 256, Walker (immunology, pathology, surgery)
  • Cytotoxicity, Immunologic (immunology)
  • Disease Progression
  • Immunity, Cellular (immunology)
  • Killer Cells, Natural (immunology)
  • Laparotomy
  • Male
  • Peritoneal Neoplasms (immunology, pathology, surgery)
  • Pneumoperitoneum, Artificial
  • Prognosis
  • Rats
  • Rats, Wistar
  • Stress, Mechanical

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