Abstract | BACKGROUND: Surgical stress promotes impaired immunological function, which contributes to tumor growth. Natural killer activity (NKA) has a protective role in immunity to tumors. So, the aim of this experimental study was to assess tumor growth and (NKA) after pneumoperitoneum and laparotomy. METHODS; Sixty male Wistar rats were divided into three groups ( anesthesia, CO2 pneumoperitoneum and laparotomy) plus ten controls. All experimental animals were inoculated subcutaneously with 8 x 105 Walker carcinosarcoma 256 cells. Animals were sacrificed on 1st(POD1) and 8th (POD8) postoperative day. Tumors were excised and weighed. RESULTS: CONCLUSIONS:
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Authors | Paulo Emilio Fuganti, Aldo Junqueira Rodrigues Júnior, Consuelo Junqueira Rodrigues, Maria Sato |
Journal | Surgical endoscopy
(Surg Endosc)
Vol. 20
Issue 12
Pg. 1858-61
(Dec 2006)
ISSN: 1432-2218 [Electronic] Germany |
PMID | 17031748
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Animals
- Carcinoma 256, Walker
(immunology, pathology, surgery)
- Cytotoxicity, Immunologic
(immunology)
- Disease Progression
- Immunity, Cellular
(immunology)
- Killer Cells, Natural
(immunology)
- Laparotomy
- Male
- Peritoneal Neoplasms
(immunology, pathology, surgery)
- Pneumoperitoneum, Artificial
- Prognosis
- Rats
- Rats, Wistar
- Stress, Mechanical
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