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Vinflunine: a new active drug for second-line treatment of advanced breast cancer. Results of a phase II and pharmacokinetic study in patients progressing after first-line anthracycline/taxane-based chemotherapy.

Abstract
To evaluate the single agent activity, pharmacokinetics and tolerability of the novel tubulin targeted agent vinflunine (VFL) (320 mg m(-2) q 21 days) as second-line chemotherapy in patients with metastatic breast carcinoma (MBC). All patients had disease progression after anthracycline/taxane (A/T) therapy. They could have received a nonanthracycline adjuvant treatment and subsequently received a first-line A/T combination for advanced/metastatic disease; or relapsed >6 months after completion of adjuvant A/T therapy and were subsequently treated with the alternative agent; or relapsed within 6 months from an adjuvant A/T combination. Objective response was documented in 18 of 60 patients enrolled (RR: 30% (95% confidence interval (CI): 18.9-43.2%)). Among the responders, seven patients had relapsed during a period of <3 months from taxane-based regimen yielding a RR of 33.3%. The median duration of response was 4.8 months (95% CI: 4.2-7.2), median progression-free survival was 3.7 months (95% CI: 2.8-4.2) and median overall survival was 14.3 months (95% CI: 9.2-19.6). The most frequent adverse event was neutropenia (grade 3 in 28.3% and grade 4 in 36.7% of patients). No febrile neutropenia was observed. Fatigue (grade 3 in 16.7% of patients) and constipation (grade 3 in 11.7% of patients) were also common; these were non-cumulative and manageable permitting achievement of a good relative dose intensity of 93.5%. Vinflunine is an active agent with acceptable tolerance in the management of MBC patients previously treated with (A/T)-based regimens. These encouraging phase II results warrant further investigation of this novel agent in combination with other active agents in this setting or in earlier stages of disease.
AuthorsM Campone, H Cortes-Funes, D Vorobiof, M Martin, C F Slabber, E Ciruelos, E Bourbouloux, C Mendiola, F M Delgado, C Colin, V Aslanis, P Fumoleau
JournalBritish journal of cancer (Br J Cancer) Vol. 95 Issue 9 Pg. 1161-6 (Nov 06 2006) ISSN: 0007-0920 [Print] England
PMID17031408 (Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • Anthracyclines
  • Bridged-Ring Compounds
  • Taxoids
  • taxane
  • vinflunine
  • Vinblastine
Topics
  • Adult
  • Aged
  • Anthracyclines (administration & dosage)
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
  • Breast Neoplasms (drug therapy, metabolism, pathology)
  • Bridged-Ring Compounds (administration & dosage)
  • Constipation (chemically induced)
  • Disease Progression
  • Female
  • Humans
  • Leukopenia (chemically induced)
  • Middle Aged
  • Nausea (chemically induced)
  • Neutropenia (chemically induced)
  • Survival Analysis
  • Taxoids (administration & dosage)
  • Treatment Outcome
  • Vinblastine (analogs & derivatives, pharmacokinetics, therapeutic use)

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