Abstract |
Ground-glass hepatocytes have been described in Lafora's disease, fibrinogen deposition, hepatitis B, type IV glycogenosis, and alcohol aversion ( cyanamide) therapy. We encountered ground-glass hepatocytes with intracytoplasmic inclusions in four liver biopsies from three transplanted patients who had none of the above-mentioned underlying diseases. One patient was a 4-year-old boy who had a kidney transplant for severe ureterovesical reflux. Patient 2 was a 52-year-old man who had two liver transplants because of hepatitis C. The third patient was a 7-month-old girl who underwent a multivisceral transplant because of necrotizing enterocolitis and liver failure induced by total parenteral nutrition. The patients developed liver abnormalities from 45 days to 4 years after their transplants. The livers showed conspicuous ground-glass hepatocytes in 90% of the children's samples and 30% of the adult liver cells. The cytoplasmic bodies stained strongly for Gomori methenamine-silver; they were positive for periodic acid-Schiff without diastase, but negative after diastase digestion. They were negative for colloidal iron and hepatitis B core and surface antigens. Electron microscopy revealed non-membrane bound aggregates of glycogen. Idiopathic ground-glass hepatocytes occur in transplanted patients and represent accumulation of altered glycogen. However, their clinical significance and cause are not entirely elucidated.
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Authors | Pablo A Bejarano, Monica T Garcia, Maria M Rodriguez, Phillip Ruiz, Andreas G Tzakis |
Journal | Virchows Archiv : an international journal of pathology
(Virchows Arch)
Vol. 449
Issue 5
Pg. 539-45
(Nov 2006)
ISSN: 0945-6317 [Print] Germany |
PMID | 17024424
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Child, Preschool
- Cytoplasm
(pathology)
- Female
- Hepatocytes
(pathology, ultrastructure)
- Humans
- Inclusion Bodies
(pathology, ultrastructure)
- Infant
- Kidney Transplantation
- Liver Glycogen
(metabolism)
- Liver Transplantation
- Male
- Middle Aged
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