Abstract | PURPOSE: METHODS: A cohort of 100 patients with gastrointestinal bleeding caused by colonic angiodysplasia was studied prospectively. The endoscopic intervention was considered successful if there was no further overt bleeding and hemoglobin concentration was stabilized (primary end point). Secondary end points were the requirement of blood transfusions, the need for surgery, bleeding-related mortality, and overall mortality. RESULTS: Overt bleeding resolved and hemoglobin levels were stabilized without transfusions or iron therapy in 85 of 100 patients (85 percent) after a median follow-up of 20 (range, 6-62) months. Transfusion requirements ceased in 90 percent of patients and only one required surgery. No patient died because of hemorrhage. In the subgroup of patients with anemia, mean hemoglobin levels increased from 9.3 (range, 5.5-12.2) g/dl before treatment to 12.6 (range, 7.4-16.7) g/dl after treatment (P < 0.01). The probability of remaining free of rebleeding at one and two year follow-up was 98 percent (95 percent confidence interval, 96-100) and 90 percent (95 percent confidence interval, 83-97), respectively. Among 118 procedures, only two complications were observed (1.7 percent). CONCLUSIONS:
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Authors | Jorge Atilio Olmos, Mariano Marcolongo, Valeria Pogorelsky, Leandro Herrera, Federico Tobal, Jorge Ricardo Dávolos |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 49
Issue 10
Pg. 1507-16
(Oct 2006)
ISSN: 0012-3706 [Print] United States |
PMID | 17024322
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Angiodysplasia
(therapy)
- Argon
- Colonic Diseases
(therapy)
- Female
- Gastrointestinal Hemorrhage
(therapy)
- Hemostasis, Endoscopic
- Humans
- Laser Coagulation
- Male
- Middle Aged
- Observation
- Prospective Studies
- Treatment Failure
- Treatment Outcome
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