Bilateral gonadoblastoma producing steroid hormones in a patient with 45,X/46,XY gonadal dysgenesis.

Abstract

A case of bilateral gonadoblastoma in a phenotypic female with 45,X/46,XY gonadal dysgenesis is presented. Hormonal investigations revealed that serum testosterone, estradiol and beta-human chorionic gonadotropin decreased following excision of the tumors, but follicle-stimulating hormone and luteinizing homrone levels increased further. Immunohistochemical staining for testosterone and estradiol was positive in both Leydig and lutein-like cells in the tumor. It is suggested that gonadoblastoma is capable of producing testosterone and estradiol, and Leydig or lutein-like cells may be the actual source of these steroid hormones.

• Authors: Y Fukamatsu, Y Tsukahara, S Hayashi, F Yoshikawa, T Fukuta
• Journal: Gynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 30 Issue 3 Pg. 189-91 ( 1990) ISSN: 0378-7346 [Print] Switzerland
• PMID: 1702401 (Publication Type: Case Reports, Journal Article)

Chemical References

• Chorionic Gonadotropin
• Chorionic Gonadotropin, beta Subunit, Human
• Peptide Fragments
• Testosterone
• Estradiol

Topics

• Adolescent
• Chorionic Gonadotropin (metabolism)
• Chorionic Gonadotropin, beta Subunit, Human
• Dysgerminoma (metabolism, pathology)
• Estradiol (metabolism)
• Female
• Gonadal Dysgenesis, Mixed (complications, pathology)
• Gonads (pathology)
• Humans
• Immunoenzyme Techniques
• Neoplasms, Multiple Primary (metabolism, pathology)
• Peptide Fragments (metabolism)
• Testosterone (metabolism)