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Involvement of 5-hydroxytryptamine1A receptors in Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice.

Abstract
The present study investigated the involvement of 5-hydroxytryptamine(1A) (5-HT(1A)) receptors in Delta(9)-tetrahydrocannabinol (THC)-induced catalepsy-like immobilization in mice. THC (10 mg/kg, i.p.) induced catalepsy-like immobilization but had no effect on motor coordination in the rota-rod test. The selective cannabinoid CB(1) receptor antagonist rimonabant (3 mg/kg, i.p.) completely antagonized THC-induced catalepsy-like immobilization. The 5-HT(1A)/5-HT(7) receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT; 0.3 and 1 mg/kg, i.p.) and 5-HT(1A) receptor partial agonist buspirone (0.06 and 0.1 mg/kg, i.p.) inhibited this THC-induced catalepsy-like immobilization. Moreover, the selective 5-HT(1A) receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohezane carboxamide dihydrochloride (WAY100635; 0.3 or 1 mg/kg, i.p.) reversed the inhibition of THC-induced catalepsy-like immobilization by 8-OH-DPAT (1 mg/kg) or buspirone (0.06 mg/kg). In contrast, the selective 5-HT(7) receptor antagonist (R)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride (SB269970) had no effect on this inhibitory effect of 8-OH-DPAT. On the other hand, WAY100635 (0.3 and 1 mg/kg, i.p.) enhanced the catalepsy-like immobilization induced by THC (6 mg/kg, i.p.). These findings suggest that the 5-HT(1A) receptors are involved in THC-induced catalepsy-like immobilization.
AuthorsNobuaki Egashira, Tomomi Matsuda, Emi Koushi, Kenichi Mishima, Katsunori Iwasaki, Yukihiro Shoyama, Michihiro Fujiwara
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 550 Issue 1-3 Pg. 117-22 (Nov 21 2006) ISSN: 0014-2999 [Print] Netherlands
PMID17022969 (Publication Type: Journal Article)
Chemical References
  • Hallucinogens
  • Phenols
  • Piperazines
  • Pyridines
  • SB 269970
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • Sulfonamides
  • Receptor, Serotonin, 5-HT1A
  • N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Dronabinol
  • Buspirone
Topics
  • 8-Hydroxy-2-(di-n-propylamino)tetralin (pharmacology)
  • Animals
  • Buspirone (pharmacology)
  • Catalepsy (chemically induced, physiopathology)
  • Dose-Response Relationship, Drug
  • Dronabinol (pharmacology)
  • Hallucinogens (pharmacology)
  • Male
  • Mice
  • Motor Activity (drug effects)
  • Phenols (pharmacology)
  • Piperazines (pharmacology)
  • Postural Balance (drug effects)
  • Pyridines (pharmacology)
  • Receptor, Serotonin, 5-HT1A (drug effects)
  • Serotonin Antagonists (pharmacology)
  • Serotonin Receptor Agonists (pharmacology)
  • Sulfonamides (pharmacology)

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