Beneficial effect of gabexate mesilate on microscopic polyangiitis with renal dysfunction and pulmonary hemorrhage: A case report.

Abstract

Corticosteroids and cyclophosphamide are the mainstay of the treatment of microscopic polyangiitis involving pulmonary hemorrhage or rapidly progressive glomerulonephritis. However, patients with advanced age are unable to tolerate this combined therapy, because of a relatively high incidence of side effects including infection, hemorrhagic cystitis, and bone marrow suppression. The authors encountered an 80-year-old patient with pulmonary hemorrhage and renal dysfunction ascribed to microscopic polyangiitis and achieved successful treatment by employing gabexate mesilate in addition to corticosteroids. The present case suggests that gabexate mesilate may be a therapeutic option for microscopic polyangiitis with progressive renal failure and pulmonary hemorrhage.

• Authors: Kiichiro Miyawaki, Jun Shiraishi, Yasuhiko Tsutsumi, Emi Shiraishi, Katsuichi Ohtsuki, Miho Inoue, Tetsuya Tatsumi, Akihiro Azuma, Hiroaki Matsubara
• Journal: Angiology (Angiology) 2006 Aug-Sep Vol. 57 Issue 4 Pg. 522-5 ISSN: 0003-3197 [Print] United States
• PMID: 17022391 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glucocorticoids
• Serine Proteinase Inhibitors
• Gabexate
• Methylprednisolone

Topics

• Aged, 80 and over
• Drug Therapy, Combination
• Gabexate (therapeutic use)
• Glucocorticoids (therapeutic use)
• Hemorrhage (drug therapy, etiology)
• Humans
• Lung (blood supply)
• Male
• Methylprednisolone (therapeutic use)
• Polyarteritis Nodosa (complications, drug therapy)
• Renal Insufficiency (drug therapy, etiology)
• Serine Proteinase Inhibitors (therapeutic use)
• Treatment Outcome