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Malaria treatment failures after artemisinin-based therapy in three expatriates: could improved manufacturer information help to decrease the risk of treatment failure?

AbstractBACKGROUND:
Artemisinin-containing therapies are highly effective against Plasmodium falciparum malaria. Insufficient numbers of tablets and inadequate package inserts result in sub-optimal dosing and possible treatment failure. This study reports the case of three, non-immune, expatriate workers with P. falciparum acquired in Africa, who failed to respond to artemisinin-based therapy. Sub-therapeutic dosing in accordance with the manufacturers' recommendations was the probable cause.
METHOD:
Manufacturers information and drug content included in twenty-five artemisinin-containing specialities were reviewed.
RESULTS:
A substantial number of manufacturers do not follow current WHO recommendations regarding treatment duration and doses.
CONCLUSION:
This study shows that drug packaging and their inserts should be improved.
AuthorsYves Jackson, François Chappuis, Louis Loutan, Walter Taylor
JournalMalaria journal (Malar J) Vol. 5 Pg. 81 ( 2006) ISSN: 1475-2875 [Electronic] England
PMID17020598 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antimalarials
  • Artemisinins
  • Ethanolamines
  • Fluorenes
  • Lactones
  • Sesquiterpenes
  • artesunate
  • artemether
  • lumefantrine
  • artemisin
Topics
  • Adult
  • Antimalarials (administration & dosage, therapeutic use)
  • Artemisinins (administration & dosage, therapeutic use)
  • Cote d'Ivoire
  • Dose-Response Relationship, Drug
  • Drug Labeling (standards)
  • Ethanolamines (administration & dosage, therapeutic use)
  • Female
  • Fluorenes (administration & dosage, therapeutic use)
  • Guidelines as Topic
  • Guinea
  • Humans
  • Lactones (administration & dosage, therapeutic use)
  • Malaria, Falciparum (drug therapy)
  • Parasitemia (drug therapy)
  • Recurrence
  • Risk
  • Sesquiterpenes (administration & dosage, therapeutic use)
  • Sudan
  • Switzerland (ethnology)
  • Treatment Failure
  • World Health Organization

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