Development of acetylated HDD kit for preparation of 188Re-HDD/lipiodol.

Abstract

A lipiodol solution of (188)Re-4-hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol ((188)Re-HDD/lipiodol) is in clinical study for liver cancer therapy. However, formulation of it is difficult due to highly active and unstable sulfhydryl groups. We produced new kits using diacetylated HDD (AHDD), in which sulfhydryl groups are protected. We found that AHDD kit can replace HDD kit due to an increased stability for formulation, the better radiolabeling efficiency (78%) and the equivalent biodistribution pattern in mice.

• Authors: Yun-Sang Lee, Jae Min Jeong, Young Joo Kim, Young Soo Chang, Hak Jeong Lee, Miwon Son, Jung Woo Lee, Heung Sik Yoon, Won Jun Kang, Dong Soo Lee, June-Key Chung, Myung Chul Lee, Young-Ger Suh
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 65 Issue 1 Pg. 64-9 (Jan 2007) ISSN: 0969-8043 [Print] England
• PMID: 17010628 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 188Re-4-hexadecyl-1,2,9,9-tetramethyl-4,7-diaza-1,10-decanethiol lipiodol conjugate
• Organometallic Compounds
• Radiopharmaceuticals
• Reagent Kits, Diagnostic
• Iodized Oil

Topics

• Acetylation
• Animals
• Equipment Design
• Equipment Failure Analysis
• Iodized Oil (chemical synthesis, pharmacokinetics, therapeutic use)
• Isotope Labeling (instrumentation, methods)
• Metabolic Clearance Rate
• Mice
• Organ Specificity
• Organometallic Compounds (chemical synthesis, pharmacokinetics, therapeutic use)
• Radiopharmaceuticals (chemical synthesis, pharmacokinetics, therapeutic use)
• Reagent Kits, Diagnostic
• Tissue Distribution