Abstract | OBJECTIVE: METHODS AND RESULTS: Atherosclerotic lesions together with different metabolic pathways involved in atherosclerosis were investigated in mice treated or not with bexarotene. Bexarotene protects from atherosclerosis development in mice, at least in part by improving the circulating cholesterol distribution profile likely via a marked decrease of dietary cholesterol absorption caused by modulation of intestinal expression of genes recently identified as major players in this process, Niemann-Pick-C1-Like1 (NPC1L1) and CD13. This atheroprotection appears despite a strong hypertriglyceridemia. Moreover, bexarotene treatment only modestly modulates inflammatory gene expression in the vascular wall, but markedly enhanced the capacity of macrophages to efflux cellular lipids. CONCLUSIONS:
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Authors | Fanny Lalloyer, Catherine Fiévet, Sophie Lestavel, Gérard Torpier, Jelske van der Veen, Véronique Touche, Stéphanie Bultel, Saïd Yous, Folkert Kuipers, Réjane Paumelle, Jean-Charles Fruchart, Bart Staels, Anne Tailleux |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 26
Issue 12
Pg. 2731-7
(Dec 2006)
ISSN: 1524-4636 [Electronic] United States |
PMID | 17008586
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ABCG1 protein, mouse
- ATP Binding Cassette Transporter, Subfamily G, Member 1
- ATP-Binding Cassette Transporters
- Apolipoprotein E2
- Lipoproteins
- Membrane Transport Proteins
- Npc1l1 protein, mouse
- Retinoid X Receptors
- Tetrahydronaphthalenes
- Triglycerides
- Cholesterol
- Bexarotene
- CD13 Antigens
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Topics |
- ATP Binding Cassette Transporter, Subfamily G, Member 1
- ATP-Binding Cassette Transporters
(genetics, metabolism)
- Animals
- Apolipoprotein E2
(genetics, metabolism)
- Atherosclerosis
(drug therapy, etiology, metabolism)
- Bexarotene
- CD13 Antigens
(genetics, metabolism)
- Cholesterol
(metabolism)
- Disease Models, Animal
- Dyslipidemias
(complications, drug therapy, metabolism)
- Female
- Gene Expression Regulation
(drug effects)
- Homeostasis
(drug effects, physiology)
- Intestinal Absorption
(drug effects)
- Lipoproteins
(genetics, metabolism)
- Membrane Transport Proteins
(genetics, metabolism)
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Retinoid X Receptors
(agonists)
- Tetrahydronaphthalenes
(pharmacology, therapeutic use)
- Triglycerides
(blood)
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