Abstract | BACKGROUND: There are limited systematic data on the incidence, clinical characteristics and outcomes of congestive heart failure (CHF) in patients with hyperthyroidism. The aim of this study was to investigate the incidence, clinical characteristics and outcome of CHF as the initial presentation in patients with primary hyperthyroidism. METHODS: The prevalence, clinical characteristics and outcome of CHF was studied in 591 consecutive patients (mean (SD) age 45 (1) years, 140 men) who presented with primary hyperthyroidism. RESULTS: CHF was the presenting condition in 34 patients (5.8%) with hyperthyroidism. The presence of atrial fibrillation at presentation (OR 37.4, 95% CI 9.72 to 144.0, p<0.001) was an independent predictor for the occurrence of CHF. Of the 34 patients with CHF, 16 (47%) had systolic left ventricular dysfunction with left ventricular ejection fraction (LVEF)<50%. They were predominantly male (OR 26.6, 95% CI 2.6 to 272.5, p = 0.006) and had a lower serum thyroxine level (OR 0.93, 95% CI 0.87 to 0.99, p = 0.044) than patients with preserved left ventricular systolic function. In these patients, LVEF (55 (4)% vs 30 (2)%, p<0.001) and New York Heart Association functional class (1.2 (0.1) vs 2.5 (0.2), p<0.001) improved significantly 3 months after achieving euthyroid status. Systolic left ventricular dysfunction (mean (SD) LVEF 38 (4)%) persisted on long-term follow-up in five PATIENTS: no clinical parameter could be identified to predict the occurrence of this persistent cardiomyopathy (p>0.05). CONCLUSION:
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Authors | Chung-Wah Siu, Chun-Yip Yeung, Chu-Pak Lau, Annie W C Kung, Hung-Fat Tse |
Journal | Heart (British Cardiac Society)
(Heart)
Vol. 93
Issue 4
Pg. 483-7
(Apr 2007)
ISSN: 1468-201X [Electronic] England |
PMID | 17005710
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Cohort Studies
- Female
- Follow-Up Studies
- Heart Failure
(etiology)
- Humans
- Hyperthyroidism
(complications)
- Male
- Middle Aged
- Prognosis
- Sex Factors
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