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[Experimental study on a novel affinity adsorbent for removal of endotoxin in plasma].

Abstract
In this paper, the adsorbent properties of Polymyxin B immobilized polystyrene microbeads to remove endotoxin from plasma were studied and the factors that affected the absorption of endotoxin were discussed. The rat models of endotoxemia were established, which were used in hemoperfusion. The experiment results indicated that the novel affinity adsorbent could remove endotoxin from plasma effectively. Moreover, the results also showed that Polymyxin B immobilized polystyrene microbeads was a fine biomaterial of hemoperfusion as well as exhibited a satisfactory blood compatibility.
AuthorsYuan Li, Xiang Wang, Xingliang Xiong, ShaoYang, Wei Gao, Shaoxi Cai
JournalSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi (Sheng Wu Yi Xue Gong Cheng Xue Za Zhi) Vol. 23 Issue 4 Pg. 832-5 (Aug 2006) ISSN: 1001-5515 [Print] China
PMID17002119 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Endotoxins
  • Polystyrenes
  • Polymyxin B
Topics
  • Adsorption
  • Animals
  • Endotoxemia (blood, therapy)
  • Endotoxins (isolation & purification)
  • Female
  • Hemoperfusion (methods)
  • Polymyxin B
  • Polystyrenes
  • Rats
  • Rats, Wistar

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