A case of resected huge ileocolonic mesenteric liposarcoma which responded to pre-operative chemotherapy using doxorubicin, cisplatin and ifosfamide.

Abstract

Primary mesenteric liposarcoma is a rare entity that has been reported only 14 times in English literature. The treatment strategy for mesenteric liposarcoma is, if no distant metastases are detected, surgical resection with a wide surgical margin, often followed by radiation and/or adjuvant chemotherapy for high-risk patients. However, the efficacy of pre-operative chemotherapy is unknown. If the tumor is shrunk by pre-operative chemotherapy, we could achieve complete surgical resection, which is difficult when the tumor is too large or is invading neighboring organs. We herein describe a case of huge mesenteric liposarcoma that showed significant tumor shrinkage by pre-operative chemotherapy using doxorubicin, cisplatin and ifosfamide, allowing a margin-negative operation.

• Authors: Seiji Ishiguro, Seiichiro Yamamoto, Hirokazu Chuman, Yoshihiro Moriya
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 36 Issue 11 Pg. 735-8 (Nov 2006) ISSN: 0368-2811 [Print] England
• PMID: 17000700 (Publication Type: Case Reports, Journal Article)

Chemical References

• Doxorubicin
• Cisplatin
• Ifosfamide

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cisplatin (administration & dosage)
• Doxorubicin (administration & dosage)
• Drug Administration Schedule
• Humans
• Ifosfamide (administration & dosage)
• Liposarcoma (diagnostic imaging, drug therapy, surgery)
• Male
• Mesentery
• Peritoneal Neoplasms (diagnostic imaging, drug therapy, surgery)
• Tomography, X-Ray Computed