Abstract | OBJECTIVE: MATERIAL AND METHODS: Male Sprague-Dawley rats were divided into two groups: totally gastrectomized and sham-operated rats. After a postoperative recovery period, rats from each group were divided into three subgroups and fed the control, DFAIII (30 g/kg), or FOS (30 g/kg) diet for 28 days. RESULTS: Total gastrectomy severely reduced net calcium absorption, femoral calcium content and bone mineral density, resulting in fragility of the femur. DFAIII or FOS feeding partly and similarly restored the lowered calcium absorption and femoral variables, with an increase in the total short-chain fatty acid pool in the cecum. In gastrectomized rats, net calcium absorption was correlated with several cecal parameters, suggesting that cecal fermentation of DFAIII is associated with the improvement in gastrectomy-induced calcium malabsorption. Urinary excretion of deoxypyridinoline (D-Pyr) as a marker of bone resorption was increased by gastrectomy, and the elevated D-Pyr excretion was suppressed by feeding DFAIII. CONCLUSIONS: Supplemental feeding of DFAIII partly prevents postgastrectomy osteopenia as a result of an improvement in calcium absorption. Our results suggest that the promotive effects of DFAIII on calcium absorption in the large intestine are comparable to those of FOS.
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Authors | Kazuki Shiga, Megumi Nishimukai, Fusao Tomita, Hiroshi Hara |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 41
Issue 10
Pg. 1165-73
(Oct 2006)
ISSN: 0036-5521 [Print] England |
PMID | 16990201
(Publication Type: Journal Article)
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Chemical References |
- Amino Acids
- Biomarkers
- Disaccharides
- difructose anhydride III
- deoxypyridinoline
- Calcium
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Topics |
- Amino Acids
(urine)
- Animals
- Biomarkers
(urine)
- Bone Diseases, Metabolic
(drug therapy)
- Calcium
(metabolism)
- Calcium Metabolism Disorders
(drug therapy, etiology)
- Disaccharides
(pharmacology, therapeutic use)
- Disease Models, Animal
- Gastrectomy
- Intestinal Absorption
(drug effects)
- Male
- Postoperative Complications
- Rats
- Rats, Sprague-Dawley
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