[Plasmapheresis for fulminant autoimmune hemolytic anemia with rapidly progressing disturbance of consciousness].

Abstract

A 64-year-old male was diagnosed as having autoimmune hemolytic anemia (AIHA) in December 2001. The diagnosis of AIHA was established based on the presence of anemia, hyperbilirubinemia, reticulocytosis, positive Coombs test and serum LDH elevation. Although he received steroid pulse therapy, disturbance of consciousness appeared and the anemia and icterus did not improve. Plasma exchange was carried out to eliminate antibodies as an emergency measure. The patient's symptoms were ameliorated following four courses of plasma exchange. This case represents a case of aggressive AIHA with disturbance of consciousness and refractory to conventional corticosteroid therapy. Plasma exchange rapidly led to complete remission.

• Authors: Takeshi Takahashi, Takeshi Hara, Yoriko Shimomura, Takeshi Yoshikawa, Eiichi Tomita
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 47 Issue 8 Pg. 787-9 (Aug 2006) ISSN: 0485-1439 [Print] Japan
• PMID: 16986720 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Anemia, Hemolytic, Autoimmune (complications, therapy)
• Consciousness Disorders (etiology, therapy)
• Disease Progression
• Humans
• Male
• Middle Aged
• Plasma Exchange
• Treatment Outcome