Rat strains differ in susceptibility to Ureaplasma parvum-induced urinary tract infection and struvite stone formation.
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| Abstract |
Individuals with struvite uroliths are susceptible to recurrent urinary tract infections (UTI), sepsis, and renal disease. Unfortunately, little is known about the host-specific factors that predispose to this disease. In order to develop a rodent model that can address this problem, we inoculated female Fischer 344 (F344), Lewis (LEW), Sprague-Dawley (SD), and Wistar (WIS) rats with a host-adapted strain of Ureaplasma parvum. Animals were necropsied at 2 weeks postinoculation; 100% of F344, 42% of SD, 10% of LEW, and 10% of WIS rats remained infected. Severe bladder lesions and struvite calculi were seen in 64% of F344 rats; in other rat strains, bladder lesions were mild or absent. F344 rats with struvite uroliths had the highest urinary levels of proinflammatory cytokines, such as GRO/KC, interleukin-1alpha (IL-1alpha), and IL-1beta. F344 rats without struvite stones at necropsy had milder bladder lesions and significantly lower urinary levels of proinflammatory cytokines but a more prominent inflammatory response than did other rat strains. Based on our results, struvite stone formation is linked to a robust inflammatory response that does not resolve UTI but instead promotes damage to surrounding tissues.
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| Authors | Leticia Reyes, Mary Reinhard, L J O'donell, Janet Stevens, Mary B Brown |
| Journal | Infection and immunity (Infect Immun) Vol. 74 Issue 12 Pg. 6656-64 (Dec 2006) ISSN: 0019-9567 [Print] United States |
| PMID | 16982825 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural) |
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