Abstract | STUDY OBJECTIVE: METHODS: Patients were randomized to receive either supplemental oxygen or compressed air by nasal cannula at 2 L per minute. Physicians were blinded to the gas used and end-tidal carbon dioxide (ETCO2) data. Respiratory depression was defined a priori as oxygen saturation less than 90%, ETCO2 level greater than 50 mm Hg, an absolute change from baseline of 10 mm Hg, or loss of the ETCO2 waveform. RESULTS: CONCLUSION: Supplemental oxygen did not reduce (or trend toward reducing) the incidence of hypoxia in patients moderately sedated with midazolam and fentanyl. However, our lower-than-expected rate of hypoxia limits the power of this comparison. Blinded capnography frequently identified respiratory depression undetected by the treating physicians.
|
Authors | Kenneth Deitch, Carl R Chudnofsky, Paul Dominici |
Journal | Annals of emergency medicine
(Ann Emerg Med)
Vol. 49
Issue 1
Pg. 1-8
(Jan 2007)
ISSN: 1097-6760 [Electronic] United States |
PMID | 16978741
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Analgesics, Opioid
- Hypnotics and Sedatives
- Midazolam
- Oxygen
- Fentanyl
|
Topics |
- Adolescent
- Adult
- Aged
- Analgesia
- Analgesics, Opioid
- Capnography
- Child
- Child, Preschool
- Conscious Sedation
- Double-Blind Method
- Emergency Service, Hospital
- Female
- Fentanyl
- Humans
- Hypnotics and Sedatives
- Hypoxia
(diagnosis, prevention & control)
- Male
- Midazolam
- Middle Aged
- Oxygen
(blood)
- Oxygen Inhalation Therapy
- Prospective Studies
- Research Design
- Respiratory Insufficiency
(diagnosis, epidemiology, etiology)
|