Glutathione S transferase M1 and T1 genetic polymorphisms are related to the risk of primary open-angle glaucoma: a study in a Turkish population.

Abstract

BACKGROUND:

Genetic factors and oxidative damage have been shown to have a role in the development of primary open angle glaucoma (POAG).

AIM:

To determine the effects of genetic polymorphisms of glutathione S transferase (GST)M1 and GSTT1 on the risk of POAG in a Turkish population.

METHODS:

Using a multiplex polymerase chain reaction (PCR), GSTM1 and GSTT1 gene polymorphisms were analysed in 144 patients with POAG and in 121 otherwise healthy controls of similar age.

RESULTS:

The GSTM1 positive genotype and the GSTT1 null genotype had an increased risk of developing POAG (p<0.001, OR 2.93, 95% CI 1.66 to 5.20 and OR 4.25, 95% CI 2.30 to 7.80, respectively). The risk of glaucoma also increased significantly in subjects with a combination of GSTM1 positive and GSTT1 null genotypes (p<0.001, OR 3.46, 95% CI 1.64 to 7.38).

CONCLUSION:

The GSTM1 positive genotype and GSTT1 null genotype or the combination of both may be associated with the increased risk of development of POAG in the Turkish population.

• Authors: Mustafa Unal, Mehmet Güven, Kazim Devranoğlu, Ahmet Ozaydin, Bahadir Batar, Nevbahar Tamçelik, Ebru Eroğlu Görgün, Didar Uçar, Ahmet Sarici
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 91 Issue 4 Pg. 527-30 (Apr 2007) ISSN: 0007-1161 [Print] England
• PMID: 16973661 (Publication Type: Journal Article)

Chemical References

• glutathione S-transferase T1
• Glutathione Transferase
• glutathione S-transferase M1

Topics

• Aged
• Case-Control Studies
• Female
• Genetic Predisposition to Disease
• Genotype
• Glaucoma, Open-Angle (genetics)
• Glutathione Transferase (genetics)
• Humans
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Genetic