Use of dorzolamide for patients with X-linked retinoschisis.

Abstract

PURPOSE:

To determine the value of a topical carbonic anhydrase inhibitor for the treatment of foveal lesions in patients with X-linked retinoschisis (XLRS).

METHODS:

Eight patients with XLRS and foveal cystic-appearing spaces by fundus examination and by optical coherence tomography (OCT) were treated with a topical form of carbonic anhydrase inhibitor. Changes in "foveal thickness" and "foveal zone thickness" were measured by OCT, and changes of best-corrected visual acuity were measured by Early Treatment Diabetic Retinopathy Study (ETDRS) charts.

RESULTS:

Seven of eight patients treated with 2% dorzolamide had a noticeable reduction in foveal thickness as well as cystic-appearing spaces by OCT. This reduction was found in both eyes in four of these patients and in one eye in one patient after 1 month of treatment. After an additional 1 month to 2 months of the same treatment regimen, two additional patients also had a noticeable reduction in foveal thickness as well as cystic-appearing spaces. Of these seven patients who had an improvement shown by OCT with treatment, five also had improvement of their visual acuity by >or=7 letters in at least one eye on ETDRS charts.

CONCLUSION:

The present study shows the efficacy of topical dorzolamide for treating foveal cystic-appearing lesions in patients with XLRS.

• Authors: Marsha A Apushkin, Gerald A Fishman
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 26 Issue 7 Pg. 741-5 (Sep 2006) ISSN: 0275-004X [Print] United States
• PMID: 16963845 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Carbonic Anhydrase Inhibitors
• Ophthalmic Solutions
• Sulfonamides
• Thiophenes
• dorzolamide

Topics

• Administration, Topical
• Adult
• Carbonic Anhydrase Inhibitors (therapeutic use)
• Cysts (diagnosis, drug therapy)
• Fovea Centralis (drug effects)
• Humans
• Middle Aged
• Ophthalmic Solutions (therapeutic use)
• Prospective Studies
• Retinoschisis (diagnosis, drug therapy)
• Sulfonamides (therapeutic use)
• Thiophenes (therapeutic use)
• Tomography, Optical Coherence
• Visual Acuity