Effects of a Helicobacter pylori eradication regimen on anti-platelet autoantibody response in infected and uninfected patients with idiopathic thrombocytopenic purpura.

Abstract

Thirty-seven patients with idiopathic thrombocytopenic purpura (ITP) were treated with a standard Helicobacter pylori eradication regimen irrespective of H. pylori infection. Our results indicate that platelet recovery results from the disappearance of H. pylori itself, and is mediated, in part, through suppression of anti-platelet autoantibody production.

• Authors: Atsuko Asahi, Masataka Kuwana, Hidekazu Suzuki, Toshifumi Hibi, Yutaka Kawakami, Yasuo Ikeda
• Journal: Haematologica (Haematologica) Vol. 91 Issue 10 Pg. 1436-7 (Oct 2006) ISSN: 1592-8721 [Electronic] Italy
• PMID: 16963398 (Publication Type: Comparative Study, Letter, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Antibodies, Bacterial
• Autoantibodies

Topics

• Adult
• Aged
• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Antibodies, Bacterial (biosynthesis, blood)
• Autoantibodies (biosynthesis, blood)
• Blood Platelets (drug effects, immunology, microbiology)
• Female
• Helicobacter Infections (blood, drug therapy, microbiology)
• Helicobacter pylori (drug effects, immunology)
• Humans
• Male
• Middle Aged
• Platelet Count
• Prospective Studies
• Purpura, Thrombocytopenic, Idiopathic (blood, drug therapy, microbiology)