Abstract |
We report a case of necrobiotic xanthogranuloma that responded to treatment with chlorambucil. A 56-year-old man presented with a 5-year history of multiple, mildly pruritic, brown-to-violaceous plaques with central ulceration and atrophy involving the periorbital area, extremities, and trunk. Laboratory studies showed mild leukopenia and a monoclonal gammopathy of the IgG lambda type on serum protein immunoelectrophoresis. Histopathological evaluation revealed a dense histiocytic infiltrate with hyaline necrobiosis involving the dermis with extension to the subcutis. Multiple large multinucleated giant cells and scattered lymphocytes were seen. A diagnosis of necrobiotic xanthogranuloma was established. The patient was started on chlorambucil initially at 2 mg per day. The dose was later increased to 4 mg per day, which resulted in flattening and complete resolution of his skin lesions.
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Authors | Sima Z Torabian, Nasim Fazel, Robin Knuttle |
Journal | Dermatology online journal
(Dermatol Online J)
Vol. 12
Issue 5
Pg. 11
(Sep 08 2006)
ISSN: 1087-2108 [Electronic] United States |
PMID | 16962026
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antineoplastic Agents, Alkylating
- Chlorambucil
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Topics |
- Antineoplastic Agents, Alkylating
(therapeutic use)
- Chlorambucil
(therapeutic use)
- Dose-Response Relationship, Drug
- Granuloma
(drug therapy, pathology)
- Humans
- Male
- Middle Aged
- Xanthomatosis
(drug therapy, pathology)
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