Elastosis perforans serpiginosa in a patient with trisomy 21.

Abstract

A 12-year-old girl with trisomy 21 (Downs syndrome) presented with an approximate 2-year history of an asymptomatic eruption on the right upper arm and left lateral neck that was clinically and histologically diagnostic of elastosis perforans serpiginosa (EPS). EPS is a perforating dermatosis affecting the face, ear, neck, extremities, or trunk. It occurs with greater frequency in persons with trisomy 21, as well as some other genetic syndromes and after D-penicillamine therapy. It has also been reported as a sporadic, presumably unrelated disorder in several acquired diseases.

• Authors: Jeffrey S Newman, Maxwell A Fung
• Journal: Dermatology online journal (Dermatol Online J) Vol. 12 Issue 5 Pg. 5 (Sep 08 2006) ISSN: 1087-2108 [Electronic] United States
• PMID: 16962020 (Publication Type: Case Reports, Journal Article)

Chemical References

• Elastin

Topics

• Child
• Connective Tissue Diseases (etiology, pathology)
• Down Syndrome (complications)
• Elastic Tissue (pathology)
• Elastin
• Female
• Humans
• Skin Diseases (etiology, pathology)