Autoimmune thrombocytopenia in pediatric systemic lupus erythematosus: alternative therapeutic modalities.

Abstract

Three patients with pediatric systemic lupus erythematosus (PSLE) and autoimmune thrombocytopenia (AT), who developed unacceptable side effects (pseudotumor cerebri, hypertension, excessive weight gain) from treatment with steroids, were treated successfully with vincristine (2 patients) or intravenous immunoglobulin (1 patient). All patients remained off steroids without any complications for 11 to 23 months.

• Authors: R N Lipnick, G C Tsokos, G L Bray, P H White
• Journal: Clinical and experimental rheumatology (Clin Exp Rheumatol) 1990 May-Jun Vol. 8 Issue 3 Pg. 315-9 ISSN: 0392-856X [Print] Italy
• PMID: 1696192 (Publication Type: Case Reports, Journal Article)

Chemical References

• gamma-Globulins
• Vincristine
• Prednisone

Topics

• Acute Disease
• Administration, Oral
• Adolescent
• Autoimmune Diseases (drug therapy, etiology)
• Child
• Drug Evaluation
• Female
• Humans
• Hypertension (chemically induced)
• Infusions, Intravenous
• Lupus Erythematosus, Systemic (complications, drug therapy)
• Platelet Count (drug effects)
• Prednisone (administration & dosage, adverse effects, therapeutic use)
• Pseudotumor Cerebri (chemically induced)
• Purpura, Thrombocytopenic (drug therapy, etiology)
• Recurrence
• Vincristine (administration & dosage, therapeutic use)
• Weight Gain (drug effects)
• gamma-Globulins (administration & dosage, therapeutic use)