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Association of interferon-gamma and interferon regulatory factor 1 polymorphisms with asthma in a family-based association study in Taiwan.

AbstractBACKGROUND:
Asthma is a multi-factorial disorder caused by complex interactions between genetic and environmental factors. IFN-gamma and IFN regulatory factor 1 (IRF-1) affect Th1/Th2 cytokine balance, and influence the differentiation of Th2 cells, which influence the development of asthma.
OBJECTIVE:
This study investigated CA repeats polymorphism of the IFN-gamma gene and GT repeats polymorphism of the IRF-1 gene, which may predispose individuals to asthma pathogenesis.
METHODS:
In the present study, we used the transmission/disequilibrium test (TDT) to investigate the relationship between asthma and the IFN-gamma and IRF-1 polymorphisms by studying 348 subjects composed of 232 parents and 116 asthmatic children.
RESULTS:
For global TDT test, IFN-gamma CA repeats and IRF-1 GT repeat polymorphisms showed a significant association with asthma in children (P=0.009 and 0.017, respectively). We demonstrated that 13 CA repeats (138 bp) of IFN-gamma gene and 11 GT repeats (306 bp) of IRF-1 gene are significantly preferentially transmitted to asthmatic children (T/NT=89/61, chi2=8.43, P<0.005 and T/NT=75/49, chi2=8.18, P<0.005, respectively). The offspring will have an increased risk of asthma when their parents transmit IFN-gamma 13 CA repeats (OR=1.83, P=0.009) and IRF1 11 GT repeats (OR=1.88, P=0.007) to them. But we observed that the IFN-gamma and IRF-1 polymorphisms are not associated with IgE concentrations.
CONCLUSION:
These findings provide strong evidence of which IFN-gamma CA repeat and IRF-1 GT repeat polymorphisms influence the risk of asthma for children in Taiwan.
AuthorsT-N Wang, Y-T Chu, W-Y Chen, W-W Feng, N-H Shih, C-H Hsiang, Y-C Ko
JournalClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (Clin Exp Allergy) Vol. 36 Issue 9 Pg. 1147-52 (Sep 2006) ISSN: 0954-7894 [Print] England
PMID16961714 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • IRF1 protein, human
  • Interferon Regulatory Factor-1
  • Immunoglobulin E
  • Interferon-gamma
Topics
  • Adult
  • Asthma (blood, genetics)
  • Child
  • Family Health
  • Female
  • Gene Frequency (genetics)
  • Genetic Predisposition to Disease (genetics)
  • Humans
  • Immunoglobulin E (blood)
  • Interferon Regulatory Factor-1 (genetics)
  • Interferon-gamma (genetics)
  • Linkage Disequilibrium (genetics)
  • Male
  • Phenotype
  • Polymorphism, Genetic (genetics)
  • Taiwan

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