Abstract |
Galectin-9, a member of the beta-galactoside-binding animal lectin family, is involved in various cellular biological events, including aggregation and apoptosis, adhesion of cancer cells, and dendritic cell maturation. We recently reported the relationship between galectin-9 expression in tumor tissue and distant metastasis in breast cancer. Tumors in 42 of the 84 patients were galectin-9-positive, and tumors in 19 of the 21 patients with distant metastasis were galectin-9-negative, assessed by immunohistochemistry. The cumulative distant metastasis-free survival ratio for galectin-9-positive patients was better than for the galectin-9-negative group (p < 0.0001). Multivariate analysis revealed that galectin-9 status influenced distant metastasis independent of and much more than lymph node metastasis. MCF-7 subclones with a high level of galectin-9 expression formed tight clusters during proliferation in vitro, whereas a subclone (K10) with the lowest level of galectin-9 expression did not. However, K10 cells stably transfected with a galectin-9 expression vector aggregated in nude mice as well as in culture. Ectopic expression of galectin-9 also reduced MCF-7 cell adhesion to extracellular matrix proteins.
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Authors | Akira Yamauchi, Keiichi Kontani, Minoru Kihara, Nozomu Nishi, Hiroyasu Yokomise, Mitsuomi Hirashima |
Journal | The breast journal
(Breast J)
2006 Sep-Oct
Vol. 12
Issue 5 Suppl 2
Pg. S196-200
ISSN: 1075-122X [Print] United States |
PMID | 16959001
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Galectins
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(metabolism)
- Breast Neoplasms
(epidemiology, metabolism, mortality, pathology)
- Disease-Free Survival
- Female
- Galectins
(metabolism)
- Humans
- Japan
(epidemiology)
- Medical Records
- Middle Aged
- Neoplasm Metastasis
(diagnosis)
- Neoplasm Staging
- Predictive Value of Tests
- Prognosis
- Retrospective Studies
- Survival Analysis
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