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Effects of cadmium on serum sex hormone levels in pigs.

Abstract
An inhibition of sex hormone secretion is observed in domestic animals exposed to cadmium in experimental conditions. Ninety-six gilts (Duroc x Landrace x Yorkshire, initial weight 27.59 kg) were randomly assigned into four different groups with three replications in each group (eight gilts per replication). The groups received the corn-soybean basal diet and supplemented with 0, 0.5, 5.0 and 10.0 mg/kg cadmium (as CdCl2) respectively. The feeding trial was ended when body weight of pigs was approximately 90 kg. The results showed that 10.0 mg/kg cadmium significantly decreased average daily gain (p < 0.05) and increased feed/gain ratio (p < 0.05) of pigs. Follicle-stimulating hormone, luteinizing hormone, oestradiol (E2) and progesterone levels in serum of the pigs fed the diet supplemented with 10.0 mg/kg cadmium were lower significantly than those of the control (p < 0.05). Compared with the control, no changes were found in the levels mentioned above when the pigs fed the diet supplemented with 0.5 or 5.0 mg/kg cadmium (p > 0.05). The changes of regulatory mechanism of the pituitary-ovary axis may be the result of cadmium accumulation in pituitary and ovary and should be investigated further.
AuthorsX-Y Han, Z-R Xu, Y-Z Wang, W-L Du
JournalJournal of animal physiology and animal nutrition (J Anim Physiol Anim Nutr (Berl)) Vol. 90 Issue 9-10 Pg. 380-4 (Oct 2006) ISSN: 0931-2439 [Print] Germany
PMID16958794 (Publication Type: Journal Article)
Chemical References
  • Cadmium
  • Progesterone
  • Estradiol
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
Topics
  • Animal Feed
  • Animal Nutritional Physiological Phenomena
  • Animals
  • Cadmium (pharmacology)
  • Dose-Response Relationship, Drug
  • Estradiol (blood)
  • Female
  • Follicle Stimulating Hormone (blood)
  • Luteinizing Hormone (blood)
  • Organ Size (drug effects)
  • Organ Specificity
  • Progesterone (blood)
  • Random Allocation
  • Swine (blood, growth & development)
  • Weight Gain (drug effects)

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