NF-kappaB in solid tumors.

Abstract

Cancer is a multistep process during which cells acquire genetic alterations that drive the progressive transformation of normal cells into highly malignant cells. Self-sufficiency in growth, insensitivity to anti-growth signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, tissue invasion and metastasis, are signatures of transformed cells. NF-kappaB is a key actor in tumorigenesis given its ability to control the expression and the function of a number of genes involved in these processes. Indeed, constitutive activation of NF-kappaB is a common feature of many human tumors, while its sustained activation during inflammation predisposes normal cells to neoplastic transformation. Since suppression of NF-kappaB has been shown to inhibit oncogenic potential of transformed cells, targeting it should be effective in the prevention and treatment of cancer.

• Authors: Francesco Pacifico, Antonio Leonardi
• Journal: Biochemical pharmacology (Biochem Pharmacol) Vol. 72 Issue 9 Pg. 1142-52 (Oct 30 2006) ISSN: 0006-2952 [Print] England
• PMID: 16956585 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antineoplastic Agents
• NF-kappa B

Topics

• Antineoplastic Agents (pharmacology)
• Apoptosis (physiology)
• Cell Division (physiology)
• Cell Transformation, Neoplastic (pathology)
• Gene Expression Regulation, Neoplastic
• Humans
• Inflammation (complications, metabolism)
• NF-kappa B (drug effects, metabolism, physiology)
• Neoplasms (complications, metabolism, pathology)