Abstract |
This report describes an 18-year-old man with disseminated malignant histiocytosis (MH). The patient initially attained complete remission (CR1) with conventional chemotherapy and then relapsed 14 months later. In second complete remission (CR2) 2 years and 8 months after initial diagnosis, an autologous bone marrow transplantation (ABMT) was undertaken following conditioning with the BEAM regimen. Bone marrow collected in CR2 was incubated with mafosfamide at a dose adjusted to the individual sensitivity of normal CFU-GM according to our current protocol. At the time of writing, 4 years post-transplant, this patient remains disease free. This is the first report of ABMT with marrow treated in vitro by mafosfamide in MH.
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Authors | B Cazin, N C Gorin, J P Jouet, J P Laporte, P Fenaux, M P Walter, A Najman, B Gosselin, F Bauters |
Journal | Bone marrow transplantation
(Bone Marrow Transplant)
Vol. 5
Issue 6
Pg. 431-3
(Jun 1990)
ISSN: 0268-3369 [Print] England |
PMID | 1695116
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Bleomycin
- Vincristine
- Doxorubicin
- Cyclophosphamide
- Prednisone
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Topics |
- Adolescent
- Bleomycin
(therapeutic use)
- Bone Marrow Transplantation
- Cyclophosphamide
(therapeutic use)
- Doxorubicin
(therapeutic use)
- Histiocytic Sarcoma
(drug therapy, surgery)
- Humans
- Male
- Prednisone
(therapeutic use)
- Remission Induction
- Transplantation, Autologous
- Vincristine
(therapeutic use)
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