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Successful autologous bone marrow transplantation in second remission of malignant histiocytosis.

Abstract
This report describes an 18-year-old man with disseminated malignant histiocytosis (MH). The patient initially attained complete remission (CR1) with conventional chemotherapy and then relapsed 14 months later. In second complete remission (CR2) 2 years and 8 months after initial diagnosis, an autologous bone marrow transplantation (ABMT) was undertaken following conditioning with the BEAM regimen. Bone marrow collected in CR2 was incubated with mafosfamide at a dose adjusted to the individual sensitivity of normal CFU-GM according to our current protocol. At the time of writing, 4 years post-transplant, this patient remains disease free. This is the first report of ABMT with marrow treated in vitro by mafosfamide in MH.
AuthorsB Cazin, N C Gorin, J P Jouet, J P Laporte, P Fenaux, M P Walter, A Najman, B Gosselin, F Bauters
JournalBone marrow transplantation (Bone Marrow Transplant) Vol. 5 Issue 6 Pg. 431-3 (Jun 1990) ISSN: 0268-3369 [Print] England
PMID1695116 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Bleomycin
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone
Topics
  • Adolescent
  • Bleomycin (therapeutic use)
  • Bone Marrow Transplantation
  • Cyclophosphamide (therapeutic use)
  • Doxorubicin (therapeutic use)
  • Histiocytic Sarcoma (drug therapy, surgery)
  • Humans
  • Male
  • Prednisone (therapeutic use)
  • Remission Induction
  • Transplantation, Autologous
  • Vincristine (therapeutic use)

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