Comparison of the efficacy of calcipotriol and maxacalcitol in combination with narrow-band ultraviolet B therapy for the treatment of psoriasis vulgaris.

Abstract

BACKGROUND:

Combination treatment with topical vitamin D(3) and narrow-band ultraviolet B (UVB) radiation is effective against psoriasis vulgaris. We compared the efficacy of the topical vitamin D(3) derivatives calcipotriol and maxacalcitol in combination therapy.

MATERIALS AND METHODS:

In this retrospective observational study, 21 patients admitted to Nagoya City University Hospital between April 2001 and September 2004 were enrolled.

RESULTS:

Combination treatment with calcipotriol or maxacalcitol and narrow-band UVB was effective against psoriasis vulgaris. Calcipotriol induced a more rapid improvement and required lower levels of narrow-band UVB irradiation to be effective. Serum calcium levels were slightly increased after 4 weeks of treatment, but there was no significant difference between the two groups. No other adverse effects were observed in either of the two groups.

CONCLUSION:

The findings of this retrospective observational study indicated that combination treatment with topical vitamin D(3) derivatives and narrow-band UVB is effective against psoriasis without any obvious side-effects. These findings provide further evidence that calcipotriol has advantages over maxacalcitol regarding the narrow-band UVB-accumulated treatment dose and improvement rate of psoriasis area and severity index (PASI) scores.

• Authors: Reiko Noborio, Keiko Kobayashi, Yoichi Shintani, Akimichi Morita
• Journal: Photodermatology, photoimmunology & photomedicine (Photodermatol Photoimmunol Photomed) Vol. 22 Issue 5 Pg. 262-4 (Oct 2006) ISSN: 0905-4383 [Print] England
• PMID: 16948829 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Dermatologic Agents
• calcipotriene
• Calcitriol
• maxacalcitol

Topics

• Administration, Cutaneous
• Adult
• Aged
• Aged, 80 and over
• Calcitriol (administration & dosage, analogs & derivatives)
• Combined Modality Therapy
• Dermatologic Agents (administration & dosage)
• Female
• Hospitals, University
• Humans
• Japan (epidemiology)
• Male
• Middle Aged
• Psoriasis (drug therapy, epidemiology, pathology, radiotherapy)
• Retrospective Studies
• Severity of Illness Index
• Treatment Outcome
• Ultraviolet Therapy