HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Dramatic etanercept-induced remission of relapsing febrile sciatic neuralgia related to p46l mutation of the tnfrsf1a gene.

Abstract
An adult patient experienced attacks of severe low back pain and sciatic neuralgia for several years, sometimes associated with myalgias, skin lesions, and high fever. Specific inflammatory laboratory tests were the major abnormalities. P46L mutation in the gene on chromosome 12p13 that encodes tumor necrosis factor receptor superfamily 1A (TNFRSF1A) was found. Management with anti-TNF agent was effective with a complete remission of bouts of pain and fever.
AuthorsJacques Serratrice, Christine de Roux-Serratrice, Patrick Disdier, Catherine Dodé, Pierre-Jean Weiller
JournalClinical rheumatology (Clin Rheumatol) Vol. 26 Issue 9 Pg. 1535-6 (Sep 2007) ISSN: 0770-3198 [Print] Germany
PMID16941196 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunoglobulin G
  • Receptors, Tumor Necrosis Factor
  • Receptors, Tumor Necrosis Factor, Type I
  • Tumor Necrosis Factor-alpha
  • Etanercept
Topics
  • Etanercept
  • Fever (drug therapy, genetics, immunology)
  • Humans
  • Immunoglobulin G (therapeutic use)
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Receptors, Tumor Necrosis Factor (therapeutic use)
  • Receptors, Tumor Necrosis Factor, Type I (drug effects, genetics)
  • Sciatica (complications, drug therapy, genetics)
  • Syndrome
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha (antagonists & inhibitors)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: