HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Smith-Magenis syndrome: a case report of improved sleep after treatment with beta1-adrenergic antagonists and melatonin.

Abstract
This report describes the case of a 4-year-old boy diagnosed with Smith-Magenis syndrome in whom treatment with a beta(1)-adrenergic antagonist in the morning (to suppress the diurnal melatonin secretion) and melatonin in the evening (to generate a nocturnal peak of melatonin) improved his sleep quality, evaluated by polysomnographic studies.
AuthorsRosario Carpizo, Angeles Martínez, Dolores Mediavilla, Mónica González, Araceli Abad, Emilio J Sánchez-Barceló
JournalThe Journal of pediatrics (J Pediatr) Vol. 149 Issue 3 Pg. 409-11 (Sep 2006) ISSN: 0022-3476 [Print] United States
PMID16939758 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Adrenergic beta-Antagonists
  • Antioxidants
  • Acebutolol
  • Melatonin
Topics
  • Acebutolol (administration & dosage)
  • Adrenergic beta-Antagonists (administration & dosage)
  • Antioxidants (administration & dosage)
  • Child, Preschool
  • Chromosome Deletion
  • Chromosomes, Human, Pair 17
  • Chronotherapy
  • Humans
  • Male
  • Melatonin (administration & dosage)
  • Sleep Disorders, Circadian Rhythm (drug therapy, genetics)
  • Syndrome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: