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Adipose-derived stem and progenitor cells as fillers in plastic and reconstructive surgery.

Abstract
Plastic surgeons are keenly aware of the principle "replace like with like." This principle underlies much of the rationale behind the clinical use of autologous fat transplantation, despite the procedure's drawbacks. Autologous fat transplantation is frequently used for a variety of cosmetic and reconstructive indications not limited to posttraumatic defects of the face and body, involutional disorders such as hemifacial atrophy, sequelae of radiation therapy, and many aesthetic uses such as lip and facial augmentation and wrinkle therapy. However, the limitations of fat transplantation are well known, particularly the long-term unpredictability of volume maintenance. Regenerative cell-based strategies such as those encompassing the use of stem cells hold tremendous promise for augmentation of the soft-tissue space. Preclinical studies and early clinical series show that adipose-derived stem cells offer the possibility of finally fulfilling the key principle of replacing like with like as an aesthetic filler, without the drawbacks of current technology.
AuthorsTimothy A Moseley, Min Zhu, Marc H Hedrick
JournalPlastic and reconstructive surgery (Plast Reconstr Surg) Vol. 118 Issue 3 Suppl Pg. 121S-128S (Sep 2006) ISSN: 1529-4242 [Electronic] United States
PMID16936551 (Publication Type: Journal Article, Review)
Topics
  • Adipocytes (transplantation)
  • Adipose Tissue (cytology)
  • Adult
  • Animals
  • Bone Marrow
  • Cell Differentiation
  • Cell Lineage
  • Cells, Cultured (cytology, transplantation)
  • Cicatrix (surgery)
  • Feasibility Studies
  • Female
  • Graft Survival
  • Humans
  • Lac Operon
  • Lipectomy
  • Male
  • Mice
  • Mice, Nude
  • Mice, Transgenic
  • Multipotent Stem Cells (transplantation)
  • Organ Specificity
  • Plastic Surgery Procedures (methods)
  • Rejuvenation
  • Stem Cell Transplantation (methods)
  • Tissue and Organ Harvesting
  • Transplantation, Autologous

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