Abstract | BACKGROUND: METHODS: Six double-blind, randomized clinical trials comparing bupropion (n = 662) with an SSRI (n = 655) for the treatment of MDD were pooled. Hypersomnia scores were defined as the sum of scores of the Hamilton Depression Rating Scale (HDRS) items #22, 23, and 24. Fatigue scores were defined as the score of HDRS item #13. RESULTS: There was a greater improvement in hypersomnia scores among bupropion-treated than SSRI-treated (p < .0001) or placebo-treated patients (p = .0008). There was also a greater improvement in fatigue scores among bupropion-treated (p < .0001) and SSRI-treated (p = .0005) than placebo-treated patients as well as a greater improvement in fatigue scores among bupropion-treated than SSRI-treated patients (p = .0078). Fewer bupropion-remitters than SSRI-remitters experienced residual hypersomnia (20.5% vs. 32.1%; p = .0014) or residual fatigue (19.5% vs. 30.2%; p = .0020). CONCLUSION: Treatment of MDD with the NDRI bupropion resulted in a greater resolution of sleepiness and fatigue than SSRIs treatment. Although preliminary, these results warrant prospectively designed studies examining potential differences between bupropion and the SSRIs on these specific depressive symptoms.
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Authors | George I Papakostas, David J Nutt, Lindsay A Hallett, Vivian L Tucker, Alok Krishen, Maurizio Fava |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 60
Issue 12
Pg. 1350-5
(Dec 15 2006)
ISSN: 0006-3223 [Print] United States |
PMID | 16934768
(Publication Type: Comparative Study, Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Review)
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Chemical References |
- Dopamine Uptake Inhibitors
- Serotonin Uptake Inhibitors
- Bupropion
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Topics |
- Adult
- Aged
- Bupropion
(therapeutic use)
- Depressive Disorder, Major
(complications, drug therapy, psychology)
- Disorders of Excessive Somnolence
(drug therapy, etiology, psychology)
- Dopamine Uptake Inhibitors
(therapeutic use)
- Double-Blind Method
- Female
- Humans
- Male
- Mental Fatigue
(drug therapy, etiology, psychology)
- Middle Aged
- Psychiatric Status Rating Scales
- Randomized Controlled Trials as Topic
- Selective Serotonin Reuptake Inhibitors
(therapeutic use)
- Terminology as Topic
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