Abstract | OBJECTIVE: To review diagnoses and challenges of treating patients with dementia with Lewy bodies (DLB), commonly considered the second most common form of dementia. DATA SOURCES: MEDLINE, Web of Science, and International Pharmaceutical Abstracts databases were searched in January 2006 for clinical studies, case series, case studies, letters, and review articles on the treatment of DLB. Search terms included: aripiprazole, cholinesterase inhibitors, clozapine, dementia with Lewy bodies, donepezil, galantamine, Lewy body dementia, neuroleptics, olanzapine, quetiapine, risperidone, rivastigmine, tacrine, ziprasidone. Applicable articles in the English language were reviewed. The bibliographies of these articles provided additional references. STUDY SELECTION: Articles describing studies, case series, and case studies are included in this review. DATA SYNTHESIS: DLB is commonly considered the second most common form of dementia, although some experts believe vascular dementia to be the second most common form. DLB is often under-diagnosed and misdiagnosed as Alzheimer's disease or Parkinson's related dementia. The core features of dementia with Lewy bodies are cognitive decline plus at least one of the following: fluctuations in cognition, visual hallucinations, and parkinsonism. Other supportive features include: neuroleptic sensitivity, repeated falls, syncope, transient loss of consciousness, REM sleep disturbances, depression, delusions, and nonvisual hallucinations. CONCLUSION:
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Authors | Anne-Lenora Henriksen, Clarke St Dennis, Stephen M Setter, John T Tran |
Journal | The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists
(Consult Pharm)
Vol. 21
Issue 7
Pg. 563-75
(Jul 2006)
ISSN: 0888-5109 [Print] United States |
PMID | 16934009
(Publication Type: Journal Article, Review)
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Chemical References |
- Antiparkinson Agents
- Antipsychotic Agents
- Cholinesterase Inhibitors
- Neuroprotective Agents
- Memantine
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Topics |
- Antiparkinson Agents
(therapeutic use)
- Antipsychotic Agents
(therapeutic use)
- Cholinesterase Inhibitors
(therapeutic use)
- Humans
- Lewy Body Disease
(diagnosis, drug therapy)
- Memantine
(therapeutic use)
- Neuroprotective Agents
(therapeutic use)
- Treatment Outcome
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