[Shifts in the blood coagulation during adenomectomy of the prostate].

Abstract

Hemocoagulation was studied in 116 patients with prostatic adenoma, stage II, before and 1, 4-7, 8-10 and 11-15 days after surgical intervention. Out of 77 patients exposed to routine adenomectomy, 55 persons were treated 12-14 days prior the surgery with therapeutic dosages of a vitamin A, E, C, P complex. After the operation they were given nicotinic acid in presence of the double load of vitamins A and E. Out of 39 persons exposed to urgent adenomectomy 19 patients were administered the double dosages of the same vitamins before the operation. The rest of the both groups were postsurgically given acetylsalicylic acid instead of vitamins. It was stated that the aforementioned vitamin therapy significantly decreased postsurgical blood coagulation disorders (in those who were prepared for the operation beforehand it happened before adenomectomy), improved the clinical course and outcomes of the postsurgical period. Presurgical investigations reveal an accelerated intravascular coagulation and mild manifestations of the DIC syndrome in patients with prostatic adenoma. After the operation the syndrome manifestations increase but rarely develop into stages II and III that are usually accompanied by consumption coagulopathy. To follow the syndrome progression one could use only 5 out of 13 tests defined by the authors: activated time of recalcification, prothrombin index, fibrinolytic activity, products of fibrin degradation and an ethanol test.

• Authors: V M Shafer, G Ia Lerner, A Sh Byshevskiĭ, S L Galian, A Iu Derevnina
• Journal: Urologiia i nefrologiia (Urol Nefrol (Mosk)) 1990 Jan-Feb Issue 1 Pg. 48-52 ISSN: 0042-1154 [Print] Russia (Federation)
• Vernacular Title: Gemokoaguliatsionnye sdvigi pri adenoméktomii predstatel'noĭ zhelezy.
• PMID: 1692431 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Vitamins

Topics

• Adult
• Blood Coagulation (drug effects)
• Blood Coagulation Disorders (blood, etiology, prevention & control)
• Combined Modality Therapy
• Emergencies
• Humans
• Male
• Middle Aged
• Patient Care Planning
• Postoperative Care
• Postoperative Complications (blood, etiology, prevention & control)
• Preoperative Care
• Prostatectomy
• Prostatic Hyperplasia (blood, complications, surgery)
• Vitamins (therapeutic use)