Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats.

Abstract

AIM:

To investigate the effects of caffeic acid on early and delayed injuries after focal cerebral ischemia in rats, and the possible relation to 5-lipoxygenase inhibition.

METHODS:

Transient focal cerebral ischemia was induced by middle cerebral artery occlusion in Sprague-Dawley rats. Caffeic acid (10 and 50 mg/kg) was ip injected for 5 d after ischemia. The brain injuries were observed, and the levels of cysteinyl leukotrienes and leukotriene B4 in the brain tissue were measured.

RESULTS:

Caffeic acid (50 mg/kg) ameliorated neurological dysfunction and neuron loss, and decreased infarct volume 24 h after ischemia; it attenuated brain atrophy, infarct volume, and particularly astrocyte proliferation 14 d after ischemia. In addition, it reduced the production of leukotrienes (5-lipoxygenase metabolites) in the ischemic hemispheres 3 h and 7 d after ischemia.

CONCLUSION:

Caffeic acid has protective effect on both early and delayed injuries after focal cerebral ischemia in rats; and this effect may partly relate to 5-lipoxygenase inhibition.

• Authors: Yu Zhou, San-hua Fang, Yi-lu Ye, Li-sheng Chu, Wei-ping Zhang, Meng-ling Wang, Er-qing Wei
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 27 Issue 9 Pg. 1103-10 (Sep 2006) ISSN: 1671-4083 [Print] United States
• PMID: 16923329 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Caffeic Acids
• Leukotrienes
• Neuroprotective Agents
• cysteinyl-leukotriene
• Leukotriene B4
• Arachidonate 5-Lipoxygenase
• Cysteine
• caffeic acid

Topics

• Animals
• Antioxidants (pharmacology)
• Arachidonate 5-Lipoxygenase (metabolism)
• Brain (pathology)
• Caffeic Acids (pharmacology)
• Cysteine (metabolism)
• Infarction, Middle Cerebral Artery (complications)
• Ischemic Attack, Transient (etiology, metabolism, pathology)
• Leukotriene B4 (metabolism)
• Leukotrienes (metabolism)
• Male
• Neurons (drug effects)
• Neuroprotective Agents (pharmacology)
• Rats
• Rats, Sprague-Dawley