Cytokeratin expression in chondroblastomas.

Abstract

The present study is based on the histopathological and immunohistochemical examination of seven chondroblastomas, including one lung metastasis occurring 9 years after treatment. Chondroblastomas were shown to co-express vimentin, S-100 protein, neuron-specific enolase, and the epithelial markers recognized by CAM 5.2, EMA and a polyclonal cytokeratin antibody. The cytokeratins present in the tumour cells of the lung metastasis were characterized as cytokeratins 8, 18, 19 and, to a lesser extent, cytokeratin 7. The results suggest aberrant cytokeratin expression in chrondroblastomas.

• Authors: H J Semmelink, M Pruszczynski, A Wiersma-van Tilburg, F Smedts, F C Ramaekers
• Journal: Histopathology (Histopathology) Vol. 16 Issue 3 Pg. 257-63 (Mar 1990) ISSN: 0309-0167 [Print] England
• PMID: 1692005 (Publication Type: Journal Article)

Chemical References

• Keratins

Topics

• Adolescent
• Adult
• Bone Neoplasms (metabolism, pathology)
• Chondroblastoma (metabolism, pathology)
• Female
• Humans
• Immunohistochemistry
• Keratins (metabolism)
• Male