Abstract | BACKGROUND: METHODS: A total of 402 treatment sessions in 127 consecutive patients undergoing PAI for HCC were prospectively studied. The incidence and risk factors associated with post-PAI fever were analyzed. RESULTS: There were 37 (9.2%) episodes of fever occurring in 29 HCC patients after PAI. Patients who developed fever more often had large-sized (3.5+/-1.3 cm vs. 2.7+/-1.2 cm, P=0.0002) tumor and a higher injection volume (2.6+/-0.1 mL vs. 2.2+/-0.1 mL, P=0.001) of acetic acid compared with those without fever. Multivariate logistic regression analysis showed that tumor size >3 cm was the only significant predictor associated with occurrence of posttreatment fever (odds ratio: 4.4, 95% confidence interval: 2.2-8.9, P<0.001). Three patients, all of whom had HCC diameter >3 cm, had 4 episodes of bacteremia after treatment; one of them developed liver abscess that required percutaneous drainage. CONCLUSIONS:
Fever after PAI is not an uncommon event. Patients with tumor size >3 cm have a higher risk of posttreatment fever. Bacteremia and significant infectious complication could occur in a minority of patients. Prophylactic antibiotics before treatment may be necessary for high-risk patients.
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Authors | Teh-Ia Huo, Yi-Hsiang Huang, Hui-Chun Huang, Jaw-Ching Wu, Pui-Ching Lee, Full-Young Chang, Shou-Dong Lee |
Journal | Journal of clinical gastroenterology
(J Clin Gastroenterol)
Vol. 40
Issue 7
Pg. 639-42
(Aug 2006)
ISSN: 0192-0790 [Print] United States |
PMID | 16917410
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Abscess
(chemically induced)
- Acetic Acid
(administration & dosage)
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Bacteremia
(chemically induced)
- Carcinoma, Hepatocellular
(drug therapy)
- Child
- Female
- Fever
(chemically induced)
- Humans
- Injections, Intralesional
- Liver Neoplasms
(drug therapy)
- Logistic Models
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
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