Thoughts on B-vitamins and dementia.

Abstract

The B-vitamins, including vitamins B12, B6, B1, B2, niacin (B3) and folate (B9), have been implicated as protective risk factors against cognitive decline and Alzheimer's disease. This commentary reviews the evidence to support protective relations of these vitamins, including consideration of known vitamin deficiency syndromes, theories of underlying biologic mechanisms, and the epidemiologic evidence. We also comment on the potential benefits and harms of vitamin supplementation as well as make recommendations for the direction of future studies.

• Authors: Martha Clare Morris, Julie A Schneider, Christine C Tangney
• Journal: Journal of Alzheimer's disease : JAD (J Alzheimers Dis) Vol. 9 Issue 4 Pg. 429-33 (Aug 2006) ISSN: 1387-2877 [Print] Netherlands
• PMID: 16917152 (Publication Type: Journal Article, Review)

Chemical References

• Vitamin B Complex
• Folic Acid

Topics

• Alzheimer Disease (metabolism, physiopathology, prevention & control)
• Dementia (metabolism, physiopathology, prevention & control)
• Folic Acid (metabolism, therapeutic use)
• Humans
• Risk Factors
• Vitamin B Complex (metabolism, physiology, therapeutic use)