Abstract | OBJECTIVES: To diagnose resistant hypertension using self-measured blood pressure (BP) at home and office BP, and to evaluate the characteristics of resistant hypertensive patients. METHODS: The subjects were 528 hypertensive patients taking at least three or more different antihypertensive drugs. Subjects were classified into four groups (controlled hypertension, isolated office resistant hypertension, isolated home resistant hypertension and sustained resistant hypertension) on the basis of the cut-off values of home BP (135/85 mmHg) and office BP (140/90 mmHg). The relationship between each resistant hypertension group and various factors was analysed using univariate and multivariate analyses. RESULTS: CONCLUSIONS: The present study demonstrated that resistant hypertension is mediated at least partly by the white-coat effect. Home BP measurements and other relevant factors associated with resistant hypertension, such as relatively higher office SBP, type of drugs prescribed, and cardiovascular complications, should be taken into account for the diagnosis and treatment of resistant hypertension.
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Authors | Takuya Oikawa, Taku Obara, Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Hirohito Metoki, Rie Komai, Kayo Murai, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai, J-HOME Study Group |
Journal | Journal of hypertension
(J Hypertens)
Vol. 24
Issue 9
Pg. 1737-43
(Sep 2006)
ISSN: 0263-6352 [Print] England |
PMID | 16915022
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Antihypertensive Agents
(pharmacology)
- Blood Pressure
- Blood Pressure Determination
(methods)
- Blood Pressure Monitoring, Ambulatory
(methods)
- Female
- Humans
- Hypertension
(diagnosis, pathology)
- Male
- Middle Aged
- Office Visits
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