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Differential changes in tachykinins after kainic acid-induced seizures in the rat.

Abstract
Changes in concentrations of the tachykinins substance P, neurokinin A and neurokinin B were investigated in rat brains after kainic acid-induced seizures. Two different antisera, one detecting substance P specifically and one recognizing neurokinins A and B but not substance P, were used. Subsequently to the acute seizures (3 h after kainic acid) significant decreases (by 25-40%) in total neurokinin (A + B) and substance P immunoreactivities were observed in the frontal cortex, dorsal hippocampus and striatum. Depending on the brain area neurokinin immunoreactivity recovered 1-3 days after injection of the toxin and was significantly increased in the frontal cortex (by 40-60%) and the hippocampus (by 100-300%) after 10-60 days. Further analysis by high pressure liquid chromatography revealed that increases in both neurokinin A and neurokinin B concentrations contributed to the increases in total neurokinin immunoreactivity 30 days after kainic acid. At the same time significantly increased levels were also observed for substance P in the frontal cortex (by 30%). Furthermore, increases were also observed in the concentrations of neuropeptide K and gamma-preprotachykinin-A(72-92) in the frontal cortex and the hippocampus 30 days after the kainic acid treatment.
AuthorsG Sperk, J Marksteiner, A Saria, C Humpel
JournalNeuroscience (Neuroscience) Vol. 34 Issue 1 Pg. 219-24 ( 1990) ISSN: 0306-4522 [Print] United States
PMID1691465 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Tachykinins
  • Substance P
  • Kainic Acid
Topics
  • Animals
  • Brain (drug effects, metabolism, physiopathology)
  • Kainic Acid
  • Male
  • Radioimmunoassay
  • Rats
  • Rats, Inbred Strains
  • Seizures (chemically induced, metabolism)
  • Substance P (metabolism)
  • Tachykinins (metabolism)

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