A boy with acute lymphoblastic leukemia acquired clonal and nonclonal cytogenetic abnormalities including del(7q) and del(20q) without clinical evidence of disease after sex-mismatched cord blood transplantation.

Abstract

An 8-year-old boy was diagnosed with precursor B-cell acute lymphoblastic leukemia. After intensified chemotherapy, he underwent sex-mismatched allogeneic cord blood transplantation. Postcord blood transplantation cytogenetic studies revealed engraftment failure evidenced by switching into the recipient type (XY), and, notably, various complex chromosomal aberrations in the recipient cells. Nonclonal and clonal aberrations including deletions of 7q and 20q were persistently observed. Nonetheless, the patient was clinically stable without evidence of marrow dysplasia or leukemic cells. Del(7q) and del(20q), 2 recurrent chromosomal aberrations in myeloid neoplasia, might represent underlying genomic instability in this patient, not the direct culprits of dysplasia or leukemogenesis.

• Authors: In-Suk Kim, Hee-Jin Kim, Keon-Hee Yoo, Ki-Woong Sung, Sun-Hee Kim
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 28 Issue 8 Pg. 540-3 (Aug 2006) ISSN: 1077-4114 [Print] United States
• PMID: 16912597 (Publication Type: Case Reports, Journal Article)

Topics

• Blood Group Incompatibility (pathology)
• Burkitt Lymphoma (genetics)
• Child
• Chromosome Aberrations
• Chromosome Deletion
• Chromosomes, Human, Pair 20 (genetics)
• Chromosomes, Human, Pair 7 (genetics)
• Cord Blood Stem Cell Transplantation (adverse effects)
• Histocompatibility Testing (methods)
• Humans
• Male
• Remission Induction
• Sensitivity and Specificity
• Tomography, X-Ray Computed (methods)
• Transplantation Conditioning (methods)
• Transplantation, Homologous
• Treatment Outcome