[A case of partial response in liver metastatic lesion from gastric endocrine cell carcinoma treated with TS-1].

Abstract

Endocrine cell carcinoma (ECC) of the stomach is a rare pathological type with a poor outcome. Standard chemotherapy has not yet been established. We experienced a case of partial response in the liver metastasis from the gastric ECC treated with TS-1. The patient was a 68-year-old female. An upper GI series and gastroendoscopy revealed pyrolus stenosis and CT-scan showed liver metastasis. A non-curative total gastrectomy was performed to allow oral intake. Since the histopathological examination revealed that tumor cells were partially positive for chromogranin A on immunohistochemical study, we diagnosed tumor ECC of the stomach. The patient with liver metastasis was treated using TS-1, and CT-scan showed a remarkable decrease (PR) in the metastatic lesion. TS-1 administration can improve the clinical outcome for ECC of the stomach.

• Authors: Norihisa Hanada, Katsuhiko Inoue, Tomofumi Osako, Kazumi Kuriwaki, Shohei Shimajiri, Mizuho Mochinaga
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 33 Issue 8 Pg. 1143-6 (Aug 2006) ISSN: 0385-0684 [Print] Japan
• PMID: 16912536 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid

Topics

• Aged
• Antimetabolites, Antineoplastic (administration & dosage)
• Carcinoma, Small Cell (drug therapy, secondary, surgery)
• Combined Modality Therapy
• Drug Administration Schedule
• Drug Combinations
• Female
• Gastrectomy
• Humans
• Liver Neoplasms (drug therapy, secondary)
• Oxonic Acid (administration & dosage)
• Remission Induction
• Stomach Neoplasms (drug therapy, pathology, surgery)
• Tegafur (administration & dosage)