Abstract | OBJECTIVES: To evaluate the efficacy and safety of lithium in the treatment of thyrotoxicosis, and to study the dose and serum levels at which therapeutic response occurs. DESIGN: Retrospective study. SETTING: Thyroid clinic of a regional hospital in Hong Kong. PATIENTS: Thirteen patients with thyrotoxicosis pending therapy with radioiodine or surgery, in whom thionamides were contra-indicated due to adverse reactions or failure of treatment. MAIN OUTCOME MEASURES: RESULTS: A satisfactory response, defined as a fall by 40% or more in free thyroxine levels and clinical improvement, was achieved in eight patients within 1 to 2 weeks of lithium therapy. In four others, response occurred in 3 to 5 weeks. Response was slow and inadequate in one patient due to 'escape'. The median dosage of lithium was 750 mg daily, with a range of 500 to 1500 mg daily. The median serum lithium level was 0.63 mmol/L. Lithium toxicity was observed in one patient. CONCLUSIONS: A relatively low dose of lithium offers a safe and effective alternative means of controlling thyrotoxicosis in patients who cannot tolerate or do not respond to thionamides.
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Authors | Y W Ng, S C Tiu, K L Choi, F Kw Chan, C H Choi, P S Kong, C M Ng, C C Shek |
Journal | Hong Kong medical journal = Xianggang yi xue za zhi
(Hong Kong Med J)
Vol. 12
Issue 4
Pg. 254-9
(Aug 2006)
ISSN: 1024-2708 [Print] China |
PMID | 16912350
(Publication Type: Journal Article)
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Chemical References |
- Iodine Radioisotopes
- Lithium Compounds
- Thyroxine
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Topics |
- Adolescent
- Adult
- Female
- Humans
- Iodine Radioisotopes
(therapeutic use)
- Lithium Compounds
(adverse effects, blood, therapeutic use)
- Male
- Middle Aged
- Retrospective Studies
- Thyrotoxicosis
(drug therapy)
- Thyroxine
(blood)
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