Abstract | PURPOSE: SETTING: The setting for this study was the Storm Eye Institute and Magill Research Center for Vision Correction, Medical University of South Carolina (Charleston, SC). METHODS: This work was a prospective, double-masked study that included 40 eyes of 40 patients randomly assigned to receive topical treatment with 0.4% ketorolac or 0.5% ketorolac, starting 15 min prior to routine phacoemulsification and foldable posterior chamber intraocular lens implantation. Following the procedure, patients were instructed to use the assigned treatment agent 4 times a day after surgery for 1 week and twice a day for 3 weeks, when drops were discontinued. Slit-lamp examination, intraocular pressure (IOP), laser cell and flare measurements, and subjective patient tolerance were evaluated postoperatively at 1, 7, and 30 d. Comparisons between the 2 groups were made at each visit, as well as comparisons to baseline. A P=value less than .05 was considered statistically significant. RESULTS: At day 1, a higher percentage of patients (70% vs. 40%) reported symptoms (mainly foreign body sensation and stinging/burning) in the 0.5% ketorolac group, compared to the 0.4% ketorolac group. No significant differences were found between the 2 groups over time regarding best-corrected visual acuity (BCVA), IOP, slit-lamp assessment of cells, and cell and flare measured using the laser cell/flare meter. CONCLUSIONS:
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Authors | Helga P Sandoval, Luis E Fernández De Castro, David T Vroman, Kerry D Solomon |
Journal | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
(J Ocul Pharmacol Ther)
Vol. 22
Issue 4
Pg. 251-7
(Aug 2006)
ISSN: 1080-7683 [Print] United States |
PMID | 16910866
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Ophthalmic Solutions
- Ketorolac Tromethamine
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Topics |
- Aged
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, adverse effects)
- Double-Blind Method
- Drug Evaluation
- Female
- Humans
- Inflammation
(drug therapy, physiopathology)
- Intraocular Pressure
(drug effects)
- Ketorolac Tromethamine
(administration & dosage, adverse effects)
- Lens Implantation, Intraocular
- Male
- Ophthalmic Solutions
(administration & dosage, adverse effects)
- Patient Satisfaction
- Phacoemulsification
- Postoperative Complications
- Prospective Studies
- Treatment Outcome
- Uveitis, Anterior
(drug therapy, physiopathology)
- Visual Acuity
(drug effects)
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