The efficiency of Sairei-to for retroperitoneal fibrosis: two case reports.

Abstract

The conventional approach for management of retroperitoneal fibrosis (RF), an inflammatory process of retroperitoneal fibro-adipose tissue, leading to the compression and obstruction of the ureters and other adjacent organs is ureterolysis with omental wrapping, and an effective alternative to surgery is immunosupressive medication such as oral corticosteroids. Sairei-to (TJ-114) is a traditional herbal medicine used for the treatment of RF in Japan. It has both anti-inflammatory and anti-allergic effects. Here we report two cases of RF successfully treated with Sairei-to. One case was idiopathic and the other was caused by artificial graft-induced vasculitis. Both cases were treated with Sairei-to following the decompression of uremia by precutaneous nephrostomy or indwelling ureteral stents. There was hardly any ureteral obstruction three months after the administration of Sairei-to. They have been doing well for 12 and 26 months. Sairei-to rarely causes side effects such as immunodeficiency, gastro-duodenal ulcer and osteoporosis that often accompany long-term administration of corticosteroids. Sairei-to is a safe and effective medicine for the treatment of RF. We therefore recommend Sairei-to as an alternative for corticosteroid therapy.

• Authors: Touko Asano, Yasuhisa Fujii, Noboru Numao, Yukio Kageyama, Kazunori Kihara
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 52 Issue 7 Pg. 543-7 (Jul 2006) ISSN: 0018-1994 [Print] Japan
• PMID: 16910587 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Drugs, Chinese Herbal
• sairei-to

Topics

• Aged
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Drug Administration Schedule
• Drugs, Chinese Herbal (therapeutic use)
• Humans
• Male
• Middle Aged
• Retroperitoneal Fibrosis (drug therapy)