Abstract | AIMS: MATERIALS AND METHODS: RESULTS: The serum ICTP levels were not well correlated with the EOD scores in the total group of men, men newly diagnosed with prostate cancer, or men previously diagnosed with prostate cancer who were followed up. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of ICTP (cut-off value, 5.0 ng/ ml) of the men newly diagnosed with prostate cancer were 78.6%, 88.0%, 78.6%, and 88.0%, respectively. In these men, the specificity and PPV of ALP (cut-off value, 335 IU/l) were 100%, whereas the sensitivity and NPV of PSA (cut-off value, 40 ng/ml) were 100% in this study. The serum levels of ICTP in the men with low ALP (< 335 IU/l) and high PSA (> or = 40 ng/ ml) clearly separated the men with or without bone metastasis, as judged by bone scans. CONCLUSION: We found that the ICTP is not a superior serum marker for bone metastases compared with ALP or PSA. Our study suggests, however, that the ICTP measurement is useful in a certain subset of men with the combination of PSA and ALP in distinguishing men with bone metastasis from those without.
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Authors | A Kataoka, T Yuasa, S Kageyama, N Tsuchiya, T Habuchi, H Iwaki, M Narita, Y Okada, T Yoshiki |
Journal | Clinical oncology (Royal College of Radiologists (Great Britain))
(Clin Oncol (R Coll Radiol))
Vol. 18
Issue 6
Pg. 480-4
(Aug 2006)
ISSN: 0936-6555 [Print] England |
PMID | 16909972
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Androgen Antagonists
- Biomarkers
- Collagen Type I
- Peptides
- collagen type I trimeric cross-linked peptide
- Alkaline Phosphatase
- Prostate-Specific Antigen
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Topics |
- Aged
- Aged, 80 and over
- Alkaline Phosphatase
(blood)
- Androgen Antagonists
(therapeutic use)
- Biomarkers
(blood)
- Bone Neoplasms
(diagnosis, secondary)
- Collagen Type I
(blood)
- Disease Progression
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Peptides
(blood)
- Predictive Value of Tests
- Prostate-Specific Antigen
(blood)
- Prostatic Neoplasms
(diagnosis, drug therapy)
- Radioimmunoassay
- Retrospective Studies
- Sensitivity and Specificity
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