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Intravenous cidofovir-induced resolution of disfiguring cutaneous human papillomavirus infection.

Abstract
Human papillomavirus infection is one of the most common and most distressing cutaneous diseases in patients with HIV infection. It is also a common, and often therapeutically challenging, infection in individuals who are immunologically competent. A wide range of therapeutic options exists for treating cutaneous human papillomavirus infections, but none is uniformly effective. In this report we describe a man with HIV-1 infection and disfiguring facial verruca vulgaris who demonstrated complete clinical response to intravenous cidofovir. Our report provides further support for the use of intravenous cidofovir as therapy for treatment-resistant and/or widespread cutaneous human papillomavirus infection.
AuthorsMargaret D Kottke, Sareeta R S Parker
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 55 Issue 3 Pg. 533-6 (Sep 2006) ISSN: 1097-6787 [Electronic] United States
PMID16908370 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antiviral Agents
  • Organophosphonates
  • Cytosine
  • Cidofovir
Topics
  • Adult
  • Antiviral Agents (administration & dosage, therapeutic use)
  • Cidofovir
  • Cytosine (administration & dosage, analogs & derivatives, therapeutic use)
  • Humans
  • Injections, Intravenous
  • Male
  • Organophosphonates (administration & dosage, therapeutic use)
  • Papillomavirus Infections (drug therapy, pathology)
  • Skin Diseases, Viral (drug therapy, pathology)
  • Treatment Outcome

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