HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Randomised controlled trial of the efficacy of a metered dose inhaler with bottle spacer for bronchodilator treatment in acute lower airway obstruction.

AbstractBACKGROUND:
Inhaled bronchodilator treatment given via a metered dose inhaler (MDI) and spacer is optimal for relief of bronchoconstriction. Conventional spacers are expensive or unavailable in developing countries, but there is little information on the efficacy of low-cost spacers in young children.
OBJECTIVE:
To compare the response to bronchodilator treatment given via a conventional or a low-cost bottle spacer
METHODS:
A randomised controlled trial of the efficacy of a conventional spacer compared with a bottle spacer for bronchodilator treatment in young children with acute lower airway obstruction. Bronchodilator treatment was given from an MDI via an Aerochamber or a bottle spacer. Clinical score and oximetry recording were carried out before and after 15 min of treatment. MDI-spacer treatment was repeated up to three times, depending on clinical response, after which nebulisation was used. The primary outcome was hospitalisation.
RESULTS:
400 children, aged (median (25th-75th centile)) 12 (6-25) months, were enrolled. The number of children hospitalised (n = 60, 15%) was identical in the conventional and bottle spacer groups (n = 30, 15% in each). Secondary outcomes including change in clinical score (-2 (-3 to -1)), oxygen saturation (0 (-1 to 1)) and number of bronchodilator treatments (2 (1 to 3)) were similar in both groups. Oral corticosteroids, prescribed for 78 (19.5%) children, were given to a similar number in the conventional (37 (18.5%)) and bottle spacer groups (41 (20.5%)).
CONCLUSION:
A low-cost bottle spacer is as effective as a conventional spacer for bronchodilator treatment in young children with acute obstruction of the lower airways.
AuthorsH J Zar, S Streun, M Levin, E G Weinberg, G H Swingler
JournalArchives of disease in childhood (Arch Dis Child) Vol. 92 Issue 2 Pg. 142-6 (Feb 2007) ISSN: 1468-2044 [Electronic] England
PMID16905564 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Bronchodilator Agents
  • Glucocorticoids
  • Oxygen
Topics
  • Asthma (blood, drug therapy)
  • Bronchodilator Agents (administration & dosage)
  • Child, Preschool
  • Drug Administration Schedule
  • Drug Delivery Systems
  • Drug Therapy, Combination
  • Female
  • Glucocorticoids (administration & dosage)
  • Hospitalization (statistics & numerical data)
  • Humans
  • Infant
  • Inhalation Spacers
  • Male
  • Metered Dose Inhalers
  • Oxygen (blood)
  • Recurrence
  • Severity of Illness Index
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: